This article focuses on gender-based violence (GBV) during crises and disasters, and the reemergence of obstacles that impede the protection of human rights of vulnerable groups often resulting in an increase of GBV, particularly among women and LGBTQ+ persons. It examines four of the 2020 transgender murders in the United States that occurred in Puerto Rico. By exploring how restriction of movement during times of crises affect the human rights of women and LGBTQ+ persons, it emphasizes the particular vulnerability of transgender persons. It offers a web based research platform, The Domestic Violence Project, as an example of efforts youth and community based organizations can explore to ensure the promotion, protection, and safety of vulnerable groups, particularly women and LGBTQ+ persons during quarantine periods including COVID-19, and proposes recommendations to nation-states, local governments, and communities.